Fujifilm has confirmed on several occasions that it has no intention of producing a full frame camera. What Fujifilm has done instead is produce some of the best APS-C and medium format cameras. The most remarkable thing Fujifilm accomplished was to bring down the overall price of medium format cameras. The GFX 50 series of cameras are the most notable.
The Fujifilm GFX 50S II is the latest medium format camera from the company. Although it continues with the same sensor and retains the contrast-detect autofocus system, the update and price point make it an enticing option. Features such as the in-body image stabilization, pixel shift, and improved autofocus could be enough for some, especially when you consider its price.
At $3,999, the GFX 50S II sits comfortably among several high-end full frame cameras. If image quality is a strict concern, then it's pretty difficult to find better value for money.
A recent video from Kai Wong discusses some of the improvements in the new Fujifilm GFX 50S II. The improvements to autofocus seem to stand out the most. Despite it being contrast detect, Wong discusses how it's much snappier, making it more effective for a wider range of photography.
Of course, full frame cameras still hold advantages over medium format cameras. However, as Fujifilm continues to develop the sector, it may become more prudent to purchase a medium format system instead of full frame.